Simulated pathogenic conformational switch regions matched well with the biochemical findings
نویسندگان
چکیده
منابع مشابه
Switch Region for Pathogenic Structural Change in Conformational Disease and Its Prediction
Many diseases are believed to be related to abnormal protein folding. In the first step of such pathogenic structural changes, misfolding occurs in regions important for the stability of the native structure. This destabilizes the normal protein conformation, while exposing the previously hidden aggregation-prone regions, leading to subsequent errors in the folding pathway. Sites involved in th...
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ژورنال
عنوان ژورنال: Journal of Biomedical Informatics
سال: 2010
ISSN: 1532-0464
DOI: 10.1016/j.jbi.2009.12.003